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Heng, B

In a neonatal rat hypoxicischemic brain injury (HIBI) model, hydrogen significantly reduced the Bax/Bcl-2 ratio by up-regulating the expression of the anti-apoptotic protein Bcl-2, while down-regulating the expression of the pro-apoptotic protein Bax and the apoptosis-executing enzyme caspase-3, leading to a reduction in apoptosis (Wang et al., 2020)

Data analysis Data analysis and its graphical representation was done using GraphPad Prism version 9 and 10

Spontaneous alternation (memory index) of experimental animals administered sweeteners [sucrose (15% and 30%), aspartame (3.5% and 7.0%), date (10% and 20%), erythritol (15% and 30%), and stevia (2.5% and 5.0%)] using the Y-Maze task

Our studies establish that glutathione metabolism modulates the efficacy of BCL-2 inhibitors